TRASTUZUMAB MOA SECRETS

The phosphorylated HER3 gives docking internet sites for p85 subunit of PI3K. The totally activated PI3K complex is generated by binding of p110 subunit of PI3K to p85 which will be able to make PIP3 by way of phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both threonine and serin p